RI per based on long-term BV data is very valuable for “personalized” diagnosis on annual health assessments. ConclusionsĬompared with weekly BV, for annual healthcare individuals, annual BV and related parameters can provide more accurate evaluation of laboratory results. The distribution range of RI per for most measurands only copied small part of RI pop with reference range index for 8 measurands <0.5. Approximately 50% measurands of II were <0.6, the utility of their RI pop were limited. Among the 18 comparable measurands, CV I estimates of annual data for 11 measurands were significantly higher than the weekly data. We have established the annual within-subject BV (CV I), RCV, II, RI per of 24 commonly used clinical chemistry and hematology analytes for healthy individuals. We used annual BV and homeostatic set point to calculate personalized reference intervals (RI per) which were compared with population-based reference intervals (RI pop). The annual BV data and derived parameters, such as reference change value (RCV) and index of individuality (II) were calculated and compared with weekly data. MethodsĪ total of 43 healthy individuals who had regular healthcare once a year for six consecutive years, were enrolled using physical, electrocardiogram, ultrasonography and laboratory. The present study determined annual biological variation (BV) and derived parameters of common laboratory analytes in order to accurately evaluate the test results of the annual healthcare population. A large number of people undergo annual health checkup but accurate laboratory criterion for evaluating their health status is limited.
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